language
绉戠爺璁烘枃
22
2025/12
Biodistribution and mechanisms of action of MF59 and MF59-like adjuvants.
杩戝勾鏉ワ紝浣滀负鐤嫍鍏抽敭缁勫垎鐨勪綈鍓傚彈鍒颁簡瓒婃潵瓒婂鐨勫叧娉ㄣ€傝嚜 1925 骞 Gaston Roman 鎻愬嚭浣愬墏姒傚康浠ユ潵锛屽凡杩囧幓杩戠櫨骞达紝鏈熼棿寮€灞曚簡澶ч噺涓庣柅鑻椾綈鍓傜浉鍏崇殑涓村簥鍓嶅拰涓村簥鐮旂┒銆傜劧鑰岋紝杩勪粖涓烘锛屽彧鏈夊皯鏁颁綈鍓傛垚鍔熷簲鐢ㄤ簬涓婂競鐤嫍銆傝繖绉嶄綆涓村簥杞寲鏁堢巼涓昏鏄敱浜庡浣愬墏鍦ㄥ鏉傜敓鐗╃郴缁熶腑鐨勪綔鐢ㄦ満鍒剁己涔忓叏闈㈡繁鍏ョ殑鐞嗚В銆備簨瀹炰笂锛孧F59 鏄涓簲鐢ㄤ簬鑾锋壒浜虹被鐤嫍鐨勯潪閾濅綈鍓傦紝鑷充粖浠嶅湪浣跨敤锛涚劧鑰岋紝鍏充簬鍏朵綔鐢ㄦ満鍒朵粛鏈夎澶氭湭鐭ャ€傚洜姝わ紝鍦ㄦ湰缁艰堪涓紝鍩轰簬鍩轰簬璇佹嵁鏀寔鐨勫厤鐤皟鑺備簨浠剁殑鏃堕棿鍜岀┖闂磋繃绋嬶紝璁ㄨ浜 MF59 鍜 MF59 鏍蜂綈鍓傜殑浣滅敤鏈哄埗鐜扮姸銆傛澶栵紝杩樻€荤粨浜嗚皟鑺備綋娑插拰缁嗚優鍏嶇柅鍙嶅簲鐨 MF59 鍜 MF59 鏍蜂綈鍓傜殑鍏抽敭鍥犵礌銆 姝ゅ锛屽熀浜庡凡鍙戣〃鐮旂┒瀵规姉鍘熷拰浣愬墏鐨勫垎甯冧笌娑堥櫎杩涜浜嗗垎鏋愶紝浠ユ繁鍏ヤ簡瑙 MF59 浣愬墏鐤嫍鐨勫畨鍏ㄦ€с€傛湰缁艰堪涓嶄粎鏈夊埄浜庢柊鍨嬭椴ㄧ儻鍩轰綈鍓傜殑寮€鍙戝強鍏跺湪涓村簥搴旂敤涓殑鍓嶆櫙锛屼篃涓烘湭鏉ュ鍏朵粬鐤嫍浣愬墏杩涜鏈哄埗鐮旂┒鎻愪緵浜嗗疂璐典环鍊笺€
22
2025/12
姘寸棙-甯︾姸鐤辩柟鐥呮瘨锛圴ZV锛夌殑鍐嶆縺娲讳細瀵艰嚧甯︾姸鐤辩柟锛圚Z锛夛紝鍙兘寮曞彂绁炵粡鐥涚瓑骞跺彂鐥囥€傚競鍞殑甯︾姸鐤辩柟浜氬崟浣嶄綈鍓傜柅鑻 Shingrix庐鍙樉钁椾繚鎶よ€佸勾浜哄厤鍙 HZ 渚靛銆傜劧鑰岋紝璇ョ柅鑻楃殑浣愬墏绯荤粺瀛樺湪灞€闄愭€э紝闇€瑕佸紑鍙戞浛浠ｄ綈鍓傜郴缁熴€傚湪杩欓」鐮旂┒涓紝鎴戜滑鍒╃敤 ELISA銆丒LISpot 鍜屾祦寮忕粏鑳炴湳鍒嗘瀽锛屽缓绔嬩簡涓€绉嶆柊鍨嬩綈鍓傜郴缁 BK-02锛岃绯荤粺鐢 Toll 鏍峰彈浣 9 (TLR9) 婵€鍔ㄥ墏 BK-02C锛圕pG2006锛夊拰涓€涓熀浜庤椴ㄧ儻鐨勬按鍖呮补涔冲墏 BK-02M锛圡F59锛夌粍鎴愩€傛垜浠殑缁撴灉琛ㄦ槑锛屽綋涓庨噸缁勬按鐥?甯︾姸鐤辩柟鐥呮瘨鐤嫍鐨勪富瑕佹垚鍒嗙硸铔嬬櫧 E (gE) 缁撳悎鏃讹紝BK-02 浣愬墏绯荤粺鑳藉婵€鍙戞樉钁楁洿楂樼殑 gE 鐗瑰紓鎬 IFN-纬+ T 缁嗚優鍙嶅簲锛?86 SFU/10鈦剁粏鑳烇紝姣斿崟鐙 gE 楂 121 鍊嶏級鍜 IgG 鎶椾綋婊村害锛圠g 婊村害 5.2锛岃€屽崟鐙 gE 涓 3.4锛夈€傚湪灏忛紶涓‘瀹氱殑璇卞 gE 铔嬬櫧鐗瑰紓鎬х粏鑳炲厤鐤殑鏈€浣冲墏閲忎负锛? 渭g gE + 30 渭g BK-02C + 1脳 BK-02M锛夈€傝繖鐩稿綋浜庝复搴婂墏閲忊€?0 渭g gE + 300/500 渭g BK-02C + 0.5 mL BK-02M銆傗€濇澶栵紝閲嶇粍姘寸棙-甯︾姸鐤辩柟鐥呮瘨鐨勬牱鍝佽妯℃牱鍝佹樉绀哄嚭姣 Shingrix庐鏇村己鐨 gE 鐗瑰紓鎬 CD4+ 鍜 CD8+ T 缁嗚優鍏嶇柅鍙嶅簲銆傛澶栵紝gE/BK-02 浣愬墏绯荤粺璇卞浜 Th1 璋冭妭鐨勬贩鍚堝厤鐤弽搴旓紝浠庤€岃兘澶熶骇鐢熷己澶х殑缁嗚優鍏嶇柅鍜屼綋娑插厤鐤€傝繖浜涘彂鐜拌〃鏄庯紝BK-02 浣愬墏绯荤粺鏄綋鍓嶆按鐥?甯︾姸鐤辩柟鐥呮瘨浜氬崟浣嶇柅鑻楃殑涓€绉嶆湁鍓嶆櫙鐨勪綈鍓傚€欓€夎€呫€
22
2025/12
鏃犻拡娉ㄥ皠绯荤粺锛圢FIS锛夋槗浜庢搷浣滐紝鍙互鍑忓皯瀵归拡澶寸殑鎭愭儳銆侼FIS 鑳藉浠ユ洿鍒嗘暎鐨勬柟寮忓鍔犳姉鍘熶笌灞€閮ㄦ敞灏勯儴浣嶅厤鐤粏鑳炵殑鐩镐簰浣滅敤锛岃繖鍙兘鏀瑰杽 mRNA鐤嫍鐨勫厤鐤弽搴斻€傚敖绠 SARS-CoV-2 mRNA 鐤嫍鍙栧緱浜嗗法澶ф垚鍔燂紝浣嗛€氱敤鐤嫍鐨勯渶姹傚崄鍒嗚揩鍒囥€傞€氳繃 NFIS 閫掗€侀€氱敤 mRNA 鐤嫍鏄簲瀵 COVID-19 鐨勯閫夋柟娉曘€傛垜浠璁″苟鍚堟垚浜嗚〃杈 BA.4銆丏elta 鍜屽師鍨 RBD 鐨 RBD3-Fc mRNA锛屼互鍙婂甫鏈 YTE 绐佸彉鐨 IgG Fc銆傞€氳繃鏃犻拡娉ㄥ皠绯荤粺锛圢FIS锛屽懡鍚嶄负 GV-01锛夌毊鍐呴€掗€侀€氱敤 RBD3-Fc 瑁 mRNA 鍜 mRNA-LNP 鐤嫍锛屼互鍙婇€氳繃閽堝ご鑲岃倝鍐呴€掗€侊紝鍦ㄨ€侀紶涓瘎浼板苟姣旇緝浜嗗叾瀹夊叏鎬у拰鍏嶇柅鍙嶅簲銆傞€氳繃涓ょ閫斿緞鏂界敤鐨勯鍓?鍔犲己鍏嶇柅鏂规浜х敓浜嗗己鐑堢殑鍏嶇柅鍙嶅簲锛岀毊鍐呴€掗€佸湪缁撳悎鎶椾綋銆佷腑鍜屾姉浣撳拰 T 缁嗚優鍙嶅簲鏂归潰鏄剧ず鍑虹浉褰撴垨鏇村ソ鐨勬€ц兘銆傝８ mRNA 鐤嫍鍏锋湁鍔熻兘鎬э紝浣嗘晥鏋滀笉濡 mRNA-LNP 鐤嫍銆備互涓婄粨鏋滆〃鏄 RBD3-Fc 鐤嫍鏄畨鍏ㄤ笖鍏锋湁鍏嶇柅鍘熸€х殑锛屾棤閽堟敞灏勭郴缁熷彲浣滀负鏇夸唬閽堝ご/娉ㄥ皠鍣紝鐢ㄤ簬鎺ョ mRNA-LNP 鐤嫍浠ユ縺鍙戝己鐑堢殑绯荤粺鎬у厤鐤弽搴斻€
26
2021/08